Ischemia (decrease in ARTERIAL blood flow ……NOT venous) Therefore – if partial pressure of O 2 is decreased, O 2 sat’n HAS to be decreased (B/c O 2 came from amount that was dissolved in plasma)ġ. O 2 flow: from alveoli through the interphase, then dissolves in plasma, and increases the partial pressure of O 2, diffuses through the RBC membrane and attaches to the heme groups on the RBC on the Hb, which is the O 2 sat’n Partial pressure of O 2 is O 2 dissolved in PLASMA O 2 sat’n is the O 2 IN the RBC is attached TO the heme group = (measured by a pulse oximeter)ģ.
In RBC, four heme groups (Fe must be +2 if Fe+ is +3, it cannot carry O 2 ) Therefore, when all four heme groups have an O 2 on it, the O 2 sat’n is 100%.Ģ. Partial pressure of arterial O 2 is O 2 dissolved in plasma In Hb, the O 2 attaches to heme group (O 2 sat’n) Oxygen content = Hb x O 2 satn + partial pressure of arterial oxygen (these are the 3 main things that carry O 2 in our blood) Protons are being kicked off, go back into the membrane, and form ATP, and ATP in formed in the mitochondriaġ. The last rxn is O 2 to receive the electrons. Need O 2 for oxidation phosphorylation pathway – where you get ATP from inner Mito membrane (electron transport system, called oxidative phosphorylation).
Hypoxia = inadequate oxygenation of tissue (same definition of as shock).
Key issues – hypoxia, cyanide poisoning, free radicals, apoptosis, growth alternations (i.e. There are many materials published by goljan which include:ġ-goljan audio lectures (goljan PATHOLOGY audio)Ĥ-Rapid Review PATHOLOGY With STUDENT Please support this website by 1, 3 or 5 $$ This file contains Typed PATHOLOGY Notes from goljan audio. GOLJAN PATHOLOGY LECTURE NOTES very important resource to prepare for USMLE s,they will help you to master and review all of the PATHOLOGY beside USMLE step 1 lecture notes PATHOLOGY.
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